$re = '/(?:\G(?!\A)|target)(?:(?!luke|(?:end)?target).)*\Kluke(?=(?:(?!(?:end)?target).)*endtarget)/m';
$str = 'targethelloluketestlukeluketestluktestingendtarget
sourcehelloluketestlukeluketestluktestingendsource';
$subst = "<SOME>";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php