$re = '/(ABCD[\w\s]+)( [a-zA-Z]+)$/m';
$str = '(C_ABCD_ehfjdhf dj hfdjhfhj and
(S_dfdfdddff 20 and
(P_ABCD_fmngfngm gfnm and';
$subst = "\1 CONSTANT\2";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php