$re = '/(.*randomwebsite\.com.*)lowquality(.*\.png)/m';
$str = 'https://randomwebsite.com/gallery/randomstring124/lowquality/imagename.png';
$subst = "$1highquality$2";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php