$re = '/(^|\n)([^|]*\|){5}(.*)/';
$str = 'note,:264058|Feb 14 2009 new document|54012|0411|2016|new document|new medicine|book store|784512|Ontario|Canada|80023569
note,:264058|Feb 14 2009 new document|54012|0411|2016|new document|new medicine|book store|784512|Ontario|Canada|80023569';
$subst = "\1\3";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php