re = /(^|\n)([^|]*\|){5}(.*)/
str = 'note,:264058|Feb 14 2009 new document|54012|0411|2016|new document|new medicine|book store|784512|Ontario|Canada|80023569
note,:264058|Feb 14 2009 new document|54012|0411|2016|new document|new medicine|book store|784512|Ontario|Canada|80023569'
subst = '\\1\\3'
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html