use strict;
my $str = '123456789.1
123456789
1.1
10.1
100.1
1000.1
10000.11
100000.1111111111
1000000.111
10000000.11111.1111
100000000.111111
1000000000.1111111
123456789
1
10
100
1000
10000
100000
1000000
10000000
100000000
1000000000';
my $regex = qr/\.\d+(*SKIP)(*FAIL)|\B(?=(?:\d{3})+(?!\d))/mp;
my $subst = ',';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html