$re = '/((?:[^,]*,){3})([^,]*)(,.*)/x';
$str = 'a,b,c,d,e,f
1,2,3,4,5,6
cat,dog,mouse,elaphant,squirrel,wookiee';
$subst = "$1col 4($2) has been edited$3";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php