# If you'd like to omit non-matching lines from the result; add ';d' to the end of the expression.
sed -E 's/^[^\s_]+_[^\s_]+\K_/x/gm;t' <<< "123_456_789.jpg
3210_5325_aa.jpg
54321-0888_555_1111.jpg"
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for SED, please visit: https://www.gnu.org/software/sed/manual/html_node/The-_0022s_0022-Command.html