use strict;
my $str = 'Hello {{first-name}}, how are you?
Hello {{first-name, last-name}}, how are you?
Hello {{-name, name-}} how are you?
Hello {{first}}-{{last}}, how are you?';
my $regex = qr/(?<=[^{])\-(?=[^{}]+}})/mp;
my $subst = '_';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html