$re = '/\/s\d+x\d+\//';
$str = 'cd.com/vp/3070d0210e464e/5AEFB3ED/t51.2885/s150x150/24845474_1790806444289980_66798452736_n.jpg
';
$subst = "/s720x720/";
$result = preg_replace($re, $subst, $str, 1);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php