$re = '/(?:^\.+|(\.)\.+)/m';
$str = '543.210.987.654.321
43.210.987.654.321
987.654...321
87.654...321
7.654...321
654....321
54....321
4....321
....321
21
1
';
$subst = "$1";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php