use strict;
my $str = '1,2,3,"a,b,c,d,e",4,"f,g,h"';
my $regex = qr`["'][\s\S]+?["']`mp;
my $subst = '';
my $result = $str =~ s`$regex`$subst`rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html