use strict;
my $str = 's1 sA s3 s@';
my $regex = qr/(s1|s2|s3|s4)|(sA|sB|sC|sD)|(s@|s#|s\$|s%)/mp;
my $subst = '${1:+s5}${2:+sE}${3:+s£}';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html