$re = '/(\b(\w+@.*.com)\b.*)\2\b/m';
$str = '999,222,999
mail,mail,nail,
mail@sca.com,mail@sca.com
site.com: mail@site.com,nail@site.com,mail@site.com
nite.com: info@nite.com,nail@site.com,nail@site.com';
$subst = "\1";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php