$re = '/A(.*?)A(.*?)A/ms';
$str = 'text A text A text A text A text A text A text A text A text A text A text ';
$subst = "B$1C$2D";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php