$re = '/^.*?(?=\d*[a-z]\d*[a-z]|$)/mi';
$str = '1234 123423-34 b4 3-z a 234 This is a test
1234 123423-34 b4 3-z a 234This is a test
1234 123423-34 b4 3-z a ';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php