$re = '/(?:\.(?![^.]+$)|[^\w\d\n.])+/m';
$str = 'manuel fernandex – Index Prot.bla.otype 5 (pepito grillo).jpg
manuel-fernandex-Index-Prot-bla-otype-5-pepito-grillo-.jpg';
$subst = "-";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php