$re = '/(?!^.*)[^a-zA-Z\s](?=.{5})/';
$str = '4567 6365 7987 3783
3457 732837 82372';
$subst = "x";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php