use strict;
my $str = '"msqlsum81pv 0 0 25 25 25 2 -sn D:\\\\workdir\\\\PV 81\\\\config\\\\sum81pv.pwf -C 5000"';
my $regex = qr/[A-Z]:.*\.\w+/p;
my $subst = '';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html