$re = '/^\/\/.*(*SKIP)(*FAIL)|("[^"]+")/m';
$str = '// eehen nhdhdhd ooe "jjejej" ejeje "keihjen" jehhemm
jejej "jejeooe" kekek "jilnana" jennbeb';
$subst = "<span class=\"red\">$1</span>";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php