use strict;
my $str = 'a<b>z</b>c<u>d</u>e<c>aa<div>a</div>aaa</c>aaa<br>aaaaaaae';
my $regex = qr~<c>.*?</c>~siup;
my $subst = ' ';
my $result = $str =~ s~$regex~$subst~rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html