$re = '~<c>.*?</c>~siu';
$str = 'a<b>z</b>c<u>d</u>e<c>aa<div>a</div>aaa</c>aaa<br>aaaaaaae';
$subst = " ";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php