const regex = new RegExp('((?:[^_]+_){2})(?=_)', 'g')
const str = `B_502_ZZZ_01
B_400__01`;
const subst = `\1ZZZ`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions