use strict;
my $str = '“@joemcelderry91: I\'ve woken up with the flu I think! :( gunna try and run it off haha!! X†get well soon joey :)';
my $regex = qr/[“â€"]/p;
my $subst = '';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html