const regex = /[a-zA-Z]{3}, ([0-9]{1,2}) ([a-zA-Z]{3}) ([0-9]{4}) [0-9]{1,2}:[0-9]{1,2}:[0-9]{1,2} [a-zA-Z]{3}/;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('[a-zA-Z]{3}, ([0-9]{1,2}) ([a-zA-Z]{3}) ([0-9]{4}) [0-9]{1,2}:[0-9]{1,2}:[0-9]{1,2} [a-zA-Z]{3}', '')
const str = `Fri, 20 Apr 2012 12:00:00 EST`;
const subst = `\2 \1, \3`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions