$re = '/ISA(?<data1>.*?)ESA.ISA(?<data2>.*?)ESA./';
$str = 'ISA~this is date~ESA|ISA~this is more data~ESA|';
$subst = "data1: ${data1}\ndata2: ${data2}";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php