re = /(.+?) +([^ ].*?) +([^ ].*?) +([^ ].*?) +([^ ].*?) {2,}([^ ].*?) {2,}([^ ].*)/
str = 'SEP111112222555 \\+49888880000222 NULL NULL t LG-COBA-DEBER01 HG_BER01 493222225555 LG-COBA-DEBER01 HG_BER01 493222225555'
subst = '\\1, \\2, \\3, \\4, \\5, \\6, \\7'
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html