$re = '/(?m)^[\d]+.+\R/u';
$str = '1576
01:14:04,440 --> 01:14:05,780
what\'s optimal daily allowance means. Which is good for 100 reasons.
1577
01:14:06,380 --> 01:14:09,970
That it\'s got to be much stronger than the RDA the recommended';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php