$re = '/(\/folder\/[^?]+\?)[^=\s]+=[^=\s]+=[^&\s]+&.*(?=\s|$)/m';
$str = 'domain.com/folder/random-text-1?A1=A2=A3&A4
domain.com/folder/random-text-2?B1=B2=B3&B4=B2';
$subst = "\1REPLACE-1=REPLACE-2=REPLACE-3&REPLACE-4";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php