$re = '/#define (Facility\w*)\s+%%%\s+(\w+)\s+\d+/';
$str = '#define FacilityUsermodeHypervisor %%% FACILITY_USERMODE_HYPERVISOR 53
#define FACILITY_USERMODE_HYPERVISOR tty';
$subst = "z$1 = $2,";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php