const regex = /<br><br>(?!<br)/g;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('<br><br>(?!<br)', 'g')
const str = `Test1 is here<br><br>Now comes Test2<br><br>Then test 3<br><br><br>Thats it.`;
const subst = `<br>`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions