$re = '~<div class="header-info-box">\K((?:[^<]|(?!</?div).|<div(?1)</div>)*+)~m';
$str = '
<div class="header-info-box">
Разный контент, <span> включая теги</span>
<div>
<div> </div>
</div>
</div>
';
$subst = "<div class=\"hello\"></div>";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php