use strict;
my $str = '0666777888
00034666777888
0034666777888
"Date" :0';
my $regex = qr/^(?!00[1-9])0/mp;
my $subst = '2';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html