$re = '/^(\-?\d{1,3}(?:(?:\,\d{3})|\d)*(?:\.\d+)?(?:[Ee\^]\d+)?\ *)+$/m';
$str = '100
2000
45,305,201,45,2506
-10,000,000.424
2015 4 4
592 -59285 6e4
204E34
40245.243e
234ggff
Hello, World! 4
261
1293712938712938172938172391287319237192837329
3.23e4';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php