$re = '/"(.*my.website.*myfile)"/';
$str = '<a class="URL" href="http://my.website.com/a/b/cdefghijklmnopqrstuvwxyz/myfile" target="_blank">';
$subst = "";
$result = preg_replace($re, $subst, $str, 1);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php