use strict;
my $str = '[16:22:99] [Client thread/INFO]: lorem ipsum
[17:30:23] [Client thread/INFO]: 108, 46, 646, world
[17:30:23] [Client thread/INFO]: -1000, 39, 719, world
[17:30:23] [Client thread/INFO]: 927, 63, -1, world
[18:42:19] [Client thread/INFO]: dolor sit amet';
my $regex = qr/(-?\d{1,4}, -?\d{1,4}, -?\d{1,4})/mp;
my $subst = '';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html