re = /(?<!\w)\d+(?<!\")/m
str = '
"gnhgnghb grhgf ytjy 4444 rewgefgg gfbvc" 234234 =2345234
sdhjaklf382as;ldfj asda2334= 76555
=123123
:1233
"gnhgnghb grhgf ytjy4444 rewgefgg
gfbvc"
"gnhgnghb grhgf ytjy 4444 rewgefgg
gfbvc"'
subst = ''
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html