$re = '/(<.*?(?=mensagem).*?>)(.*?)(<.*?>)|(.*)/';
$str = '<span id="mensagem" class="topo">Classes e comandos</span>
<sfdfsdpan id="mendsagem" class="topo">Classes e comandos</span>
<s4856461pan id="mensagem" class="topo">AAAAAA</span>
<span id="meaaaaansagem" class="topo">VOU APRENDER REGEX</span>
<span id="mensagem" class="topo">H1234Ç.,w^</span>
<span id="mensagem" class="topo">VOU APRENDER REGEX</span>
';
$subst = "$2";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php