re = /^YOUR_ANSWER\s+.*?\s+#'END_ANSWER$/m
str = 'random text!!!!
YOUR_ANSWER
As_samp2 = 36
As_samp3 = 38
#\'END_ANSWER
not your answer'
subst = 'space for answer'
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html