re = /^[^\n\r]*?PVD-666432[^\n\r]*+\n?/mi
str = 'abc PVD-666432def
abc PVD-666432 def
abcPVD-666432
abcd efg
PVD-666432abc
ab cd ef
PVD-666432 abc'
subst = ''
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html