$re = '/(http:\/\/cfile([0-9]+)(.)([a-z]+)(.)tistory.com\/original\/([a-zA-z0-9]+))(?![\s\S]*\1)/';
$str = 'http://cfile21.uf.tistory.com/original/212BA64E563633880B731B
http://cfile21.uf.tistory.com/original/212BA64E563633880B731B
http://cfile21.uf.tistory.com/original/212BA64E563633880B731B';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php