$re = '/(?<=\d)(\d{3})(?!\d)/';
$str = '100000
?100000?50000
X10000.5?
100,000
123456789
1.9876
';
$subst = ",$1";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php