$re = '/^(\d*)\d{2}\b/m';
$str = '1091 foo address
" --> "10XX BLOCK foo address"
1016 foo 1010 address
" --> "10XX BLOCK foo 1010 address"
foo 1081 address
" --> "foo 1081 address"
10 bar address
" --> "XX BLOCK bar address"
8 baz address
" --> "8 baz address"';
$subst = "$1XX BLOCK";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php