$re = '/Date_Number\(.*\)/';
$str = 'WEEK = \'2\'
Date_Number(3,4,5,6,7,8)
AND
Allowance=\'100\'
AND
((End_Date<\'2017-09-17 00:00:00\'
AND
Saturday_Name)';
$subst = "Date_Number(22,25,27,28,29)";
$result = preg_replace($re, $subst, $str, 1);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php